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Benzodiazepini, uključujući diazepam mogu izazvati oštećenje ploda ako se uzimaju u periodu trudnoće, naročito tokom prvog i trećeg trimestra (tromesečja) trudnoće.
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Tolerancija - kod pacijenata koji dugotrajno uzimaju diazepam može se razviti tolerancija na lek (ukoliko nakon nekoliko nedelja primetite da lek pomaže manje nego na početku terapije, obratite se Vašem lekaru).
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