Poznato je da istovremena primena diazepama i kombinovanih oralnih kontraceptiva može dovesti do probojnog krvarenja. Mehanizam ove reakcije nije poznat. Nisu prijavljeni slučajevi neuspele kontracepcije.
Amnezija: Pri primeni terapijskih doza leka može se javiti anterogradna amnezija, rizik je povećan pri primeni većih doza. Efekat amnezije može biti udružen sa neprikladnim ponašanjem (videti odeljak four.four).
a buccal film, which you put among your gum and cheek to dissolve (only out there beneath the brand name identify Libervant)
Esomeprazol inhibira CYP2C19 metabolički set diazepama. Istovremena primena esomeprazola produžava poluvreme eliminacije i povećava vrednosti PIK diazepama za približno eighty%. Pojačano je dejstvo diazepama. Može biti neophodno smanjenje doze diazepama.
Using particular rest medicines with diazepam can boost your danger of drowsiness or sleepiness. It may cause your respiration to decelerate or stop. These medicine include:
Povišena je koncentracija diazepama u plazmi usled inhibicije CYP3A4 metaboličkog puta. U studiji kod zdravih dobrovoljaca primena 200 mg itrakonazola dnevno tokom four dana povećala je PIK pojedinačne oralne doze od five mg diazepama za oko 15%, ali ova interakcija nije bila od kliničkog značaja, što je potvrđeno psihomotornim testovima. Moguće je pojačano dejstvo diazepama.
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Smanjenje ili povećanje koncentracije fenitoina u serumu. Neophodno je pažljivo pratiti koncentracije fenitoina pri uvođenju ili obustavi diazepama.
Diazepam is accessible as the brand-name drug Valium. It’s also offered being a generic drug. Generic medicines typically Price a lot less. In some instances, they might not be offered in just about every energy or sort because the model-name Model.
Diazepam ne treba koristiti istovremeno sa alkoholom (pojačan sedativni efekat: negativan uticaj na sposobnost upravljanja vozilom/rukovanja mašinama).
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Entry of chloride ions causes an inhibitory likely that lessens the power of neurons to depolarize read more to the edge opportunity essential to make motion potentials. Extreme depolarization of neurons is implicated during the era and spread of seizures. It is actually believed that diazepam enhances the actions of GABA by resulting in GABA to bind extra tightly to the GABAA receptor
Geriatric Elimination half-lifetime raises by approximately one get more info hour for yearly of age starting by using a 50 percent-life of twenty hours at twenty years of age. This seems to become because of an increase in quantity of distribution with age plus a lessen in clearance. Therefore, the elderly may have lessen peak concentrations, and on many dosing increased trough concentrations.